Tough and biodegradable polyurethane-silica hybrids with a rapid sol-gel transition for bone repair

نویسندگان

چکیده

Abstract Inorganic–organic hybrid materials have promising properties for bone repair because of the covalent bonding between their inorganic and organic phases. This desirable interaction allows limitations composite materials, such as inhomogeneous biodegradation rates nonbiointeractive surfaces, to be overcome. In this study, a polycaprolactone (PCL)-based polyurethane (PU) with an organosilane functional group was synthesized first time. Thereafter, biodegradable PU-silica produced through sol-gel process. The not only flexible fully but also possessed shape memory ability. addition, allophanate enabled silane coupling agent induce increased crosslinking polymer silica network, well polymer. Accordingly, sol-to-gel gelation time required produce hybrids very short, which allowed production 3D porous scaffolds simple salt-leaching A scaffold 30 wt. % composition most ideal regenerative since it able withstand thermal deformation mechanical properties. Moreover, induced osteogenic differentiation angiogenesis accelerate regeneration.

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ژورنال

عنوان ژورنال: Npg Asia Materials

سال: 2023

ISSN: ['1884-4049', '1884-4057']

DOI: https://doi.org/10.1038/s41427-023-00475-y